David Sinclair's Stack

Cadence: Daily - ~1 g daily with fat

Dosage: Discusses resveratrol as a polyphenol studied for sirtuin activation and aging-related pathways; usage described with dietary context.

Cadence: Daily - ~1 g daily in the morning

Dosage: Uses NMN as an NAD+ precursor and frequently discusses NAD+ decline with aging.

Cadence: Daily - Typically one meal per day

Dosage: Advocates time-restricted eating as a lifestyle intervention associated with metabolic and longevity pathways.

Cadence: Daily - Low protein plant-heavy meals

Dosage: Describes a largely plant-based diet with lower protein intake, particularly during weekdays.

Cadence: Daily - Avoid alcohol

Dosage: Publicly states avoidance of alcohol due to its negative effects on aging-related pathways.

Cadence: Weekdays - Lower protein intake on weekdays

Dosage: Discusses lower protein intake to reduce mTOR signaling outside of training contexts.

Cadence: Daily - Daily movement with regular aerobic activity

Dosage: Frames regular physical activity as a core longevity behavior alongside molecular interventions.

Cadence: Occasionally - Regular cold exposure practices

Dosage: Mentions hormetic stressors such as cold exposure in discussions of resilience and longevity pathways.

Cadence: Occasionally - Periodic lab testing

Dosage: Encourages tracking metabolic and aging-related biomarkers to inform lifestyle and intervention choices.

Cadence: Daily - Low-dose prescription use

Dosage: Discusses metformin as a longevity-related drug studied in metabolic and aging contexts; requires medical supervision.

Cadence: Daily - Dietary or supplemental intake

Dosage: Discussed as a polyamine associated with autophagy and longevity pathways.

Cadence: Weekly - Regular sauna use

Dosage: Mentions heat stress as a hormetic stimulus relevant to longevity discussions.